10 Rarest Diseases in The World

There more than 6,000 rare diseases in the list of US Office of Rare Diseases today. Most of this diseases are not yet fully understood and not even been heard before by most of the people.

There are certain things in this world happen by chance. These things happen very rarely that some of us will die never knowing a thing about them. Same is true in diseases and health conditions. There are more than 6,000 rare diseases listed in the US Office of Rare Diseases today.  There is no single accepted definition accepted yet to define the term rare disease but in the United States, a certain disease can be considered rare if affects less than 200,000 people and less than 1 in 2,000 people in European Union Countries.

Because of the inimitability of these diseases and or conditions, most of them are yet to be fully understood. The following are 10 of the rarest diseases in the world:


Paraneoplastic pemphigus (PNP) was first described in 1990. It is a severely debilitating blistering disease affecting skin and mucous membranes in patients with malignancy. It is characterized by painful blisters and shed areas of the mouth, lips, esophagus and skin. It is the least common but most serious form of pemphigus, particularly considering the presence of the underlying cancer. Although there are many types of pemphigus, paraneoplastic pemphigus is the rarest with an incidence rate less than .1 per 100,000 people.


The term progeria is derived from a greek words, pro meaning “before” and gareas meaning “old age”. Hutchinson-Gilford Progeria or commonly known as progeria is an extremely uncommon hereditary disease that affects the skin, musculoskeletal system, and vasculature. It is characterized by physical appearance that develops in childhood and resembles some features of accelerated aging. At birth, children with progeria appear normal. Signs of accelerated aging begin to show as the child ages. Death usually occurs as a result of complications of cardiac or cerebrovascular disease generally between six and twenty years of age, with an average life span of approximately 13 years. This condition affects only one in 8 million people around the world.

8          MORGELLONS

Morgellons disease is one of the poorly understood diseases in the world because of its rareness. Because of the same reason, much debates are currently existing whether this disease actually exist. It is a condition referred to by the Centers of Disease Control as unexplained dermopathy. It is characterized by a range of symptoms on the skin including crawling, biting, and stinging sensations; finding fibers on or under the skin; and persistent skin lesions such as rashes or sores. Because of the lack of evidence, this condition is not yet fully accepted in the medical community but their approximately 2,000 people in the United States who believe they have this disease.

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