Alzheimer Disease
Alzheimer disease (AD), a neurodegenerative disorder, is the most common form of dementia.
Alzheimer disease (AD), a neurodegenerative disorder, is the most common form of dementia, It was first described in 1906 by a psychiatrist, German and a neuropathologist Alois Alzheimer.
IMAGE SOURCE: http://www.alz.org/index.asp
This incurable disease affects mainly people over 65 years of age and is characterized clinically by a persistent and progressive decline in cognitive ability, and most commonly in memory loss, confusion, irritability violent and changing behaviour, language problems; pathologically by neuronal loss in select brain regions, neurofibrillary tangles and senile plaques.
IMAGE SOURCE: http://www.alzheimer.ca/english/alzheimer_brain_mini_site/09.htm
About the aetiology of AD, the primary hypothesis is that accumulation of amyloid-β (Aβ) peptide, a product of amyloid precursor protein (APP) processing, is the causative constituent of AD pathogenesis. The accumulation of proteins is cause of alterations related to reactive processes and losses of neurons.
IMAGE SOURCE: http://www.nature.com/nature/journal/v423/n6938/fig_tab/423392a_F1.html
Extracellular Ab accumulation occurs in the parenchyma as diffuse, focal or stellate deposits. It may involve the vessel walls of arteries, veins and capillaries.
A variety of clinico-pathological kinds of Alzheimer disease have been reported, according to the type of the lesions (plaque only and tangle predominant), the type of onset (focal onset), the cause (genetic or sporadic) and the associated lesions bodies, vascular lesions, hippocampal sclerosis, inclusions and argyrophilic grain disease).
Liked it
carla soho | Aug 28, 2009 | Reply
Very interesting article! thanks for sharing!
ageeinc | Aug 28, 2009 | Reply
Very descriptive and well formed definition of this medical Malady
webseowriters | Aug 28, 2009 | Reply
Well defined Alzheimer and APP processing . Good work Beth
Allison Jae | Aug 28, 2009 | Reply
Very informative with good illistrations.
Francois Hagnere | Aug 29, 2009 | Reply
Very educational. Thank you so much my friend,
François
Jenny Heart | Aug 30, 2009 | Reply
Well written with great informations material. Like it!
Joe Dorish | Aug 30, 2009 | Reply
Very informative article, never knew there was a doctor named Alzheimer.
Ruby Hawk | Aug 30, 2009 | Reply
it’s the saddest thing in the world. I had a friend aflected with it.
Jane Jane | Sep 1, 2009 | Reply
it’s pityful to have this. u even forgot ur loved ones..
Melody Arcamo Lagrimas | Sep 2, 2009 | Reply
This is really devastating to both the sufferer and his loved ones. Good piece.
cutedrishti8 | Sep 17, 2009 | Reply
Great information to share…Thanks
Rana Sinha | Sep 18, 2009 | Reply
Thanks for sharing. The mother of a friend is suffering from Alzheimer’s and I hear regularly how the condition is progressing. It’s hard for the family.
sunshine926 | Sep 18, 2009 | Reply
Great info.
fishfry aka Elizabeth Figueroa | Sep 24, 2009 | Reply
Very interesting article, I am awed by the way the brain changes during this illness.
Tx
Sourav | Oct 11, 2009 | Reply
Very informative article on a extremely serious topic.
mystery writter | Oct 13, 2009 | Reply
I used to work as a homemaker and saw this alot.it was hard to deal with and untill now,hard to understand.A great job on the article.