Are you aware of the fact that late maternal age can lead to a number of chromosomal abnormalities in the developing embryo?
Increasing maternal and paternal age can predispose the offspring( developing baby) to a number of chromosomal diseases such as Down’s syndrome, Marfan syndrome and Achondroplasia.
Advanced Maternal Age: ( Above 35 years):
The most common chromosomal abnormality associated with increasing maternal age is Down’s syndrome. The actual cause of Down’s syndrome is Non-dysjunction of the chromosomes during meiosis , the incidence of which is increased with the advancement in mothers age. Children with Down’s syndrome have specific features:
Clinical Findings in Down’s Syndrome patients:
1- Mental retardation (severe)
2- Epicanthal folds
3- Brushfield Spots
4- Simian crease
5- Decreased alpha fetoprotein in blood is also associated with Down’s patients.
Hope this article was informative. Find the abnormalites related to old paternal age as in my next article.