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Viboliv (Metadoxine Tablets and Injection)

Metadoxine antagonizes the lipid peroxidation in liver cells, restoring liver damage resulting horn prolonged alcohol intake and reduces fatty liver in chronic hepatitis.

Viboliv (Metadoxine Tablets and Injection)

International Non- Proprietary Name – Metadoxine

Chemical Name – Pyridoxine L -2- proliclone-5- carboxylate

Composition

Each film-coated tablet contains:

Metadoxine – 500 mg

COLOUR – litanium Dioxide IP

Viboliv Injection

Each ml contains:

Metadoxine – 500 mg

Methylparaben IP – 0.05% w/v

(As preservative)

Water for Injection IP

Mechanism of Action

Metadoxine antagonizes the lipid peroxidation in liver cells, restoring liver damage resulting horn prolonged alcohol intake and reduces fatty liver in chronic hepatitis.

Furthermore Metadoxine acts specifically on the neuro-transmitter systems involved in alcoholic intoxication, increasing the release of GABA and Acetyl Choline.

Metadoxine improves ethanol metabolism, reducing plasma ethanol levels during alcohol intake and improves the cognitive impairment, as well as the main psychological symptoms (aggressiveness, agitation, mood and behavioral disturbances) due to occasional or prolonged alcohol abuse.

Therapeutic Efficacy

Viboliv reduces the stay-time of ethanol in the organism, thus minimizing its toxic effects on cells. Viboliv also protects cell structure and function acting on those biochemical processes which defend them.

Due to these peculiar pharmacological properties, Viboliv reduces detoxification time in acute ethanol intoxication and prevents or reduces the hepatic and neuropsychic consequences of habitual intake of alcohol.

Indications

Treatment of fatty liver due to alcoholism, acute and chronic intoxication of alcohol.

Dosage and Administration

Acute ethanol intoxication

1 – 2 ampoules administered intramuscularly or intravenously.

For other indications:

2 tablets daily, administered orally, or I ampoule daily, administered intramuscularly, or intravenously.

Contraindications

Known hypersensitivity to the preparation.

Caution must be exercised in Parkinsonians treated with L-Dopa, as Viboliv may antagonize the drug’s effect.

Use during pregnancy and lactation

Viboliv should not be administered during pregnancy and lactation.

Drug Interactions

Metadoxine may increase the peripheral decarboxylation of levodopa, decreasing its efficacy.

Incompatibility

With iron salts, alkaline solutions, oxidant solutions.

Warnings

Viboliv ampoules contain sodium metabisulfite. This substance may cause allergic reactions and severe asthmatic attacks in sensitive patients, particularly in asthmatics

Storage

Store below 25 c. Protect from light & moisture

Keep out of reach of children.

Presentation

Viboliv Tablet: Strip of 10 tablets.

Viboliv Injection: Ampoule of 5ml

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