Does Periactin (Peritol) Really Promote Weight Gain?

Peritol, Cyproheptadine or Periactin has been shown in numerous studies to increase appetite significantly and stimulate weight gain.

Periactin, Peritol or Cyproheptadine is an antihistamine that can also be used to stimulate appetite and weight gain in persons who suffer from anorexia and those who have trouble gaining weight. But with all the chatter on the internet about the potential that peritol or periactin has to help you pack on the extra pounds fast, what does the medical community actually say about these drugs?

Well according to researchers T. Silverston and D. Schuyler peritol or periactin does have the ability to increase food intake and help you gain weight. Writing in the journal, Psychopharmacology 1975 40(4):355-40 titled The Effect of Cyproheptadine on Hunger, Caloric Intake and Body Weight in Man, both researchers found that not only does peritol/periactin promote weight gain, but that peritol/periactin promotes weight gain significantly. The researchers placed some subjects on a placebo and others on a 4mg periactin three times a day for one month. The subjects who took peritol/periactin three times per day for one month had significant weight gain while those on the placebo had regular weight gain or maintained their original weight.

Similarly, researchers G. Irsy and E. Szatlóczky, writing in Thur Hung in a 1977article titled The Effect of Peritol in Stimulating Appetite and Promoting Weight Gain, found that peritol/periactin does in fact help to open the appetite, increase food intake and thus promote weight gain. The research showed a marked increase in appetite stimulation and caloric intake on subjects who were given peritol/periactin over a one month period to promote weight gain.

Peritol or Periactin also shows a lot of promise when it comes to promoting weight gain in persons with anorexia and eating disorders. According to GJ Pawlowski, in the article titled Cyproheptadine: Weight Gain and Appetite Stimulation in Essential Anorexic Adults, peritol/periactin helped anorexic patients to gain weight by stimulating appetite. The results, however, were less significant than other studies on peritol/periactin on weight gain in normal, healthy adults. This may be as a result of the fact that anorexic patients’ weight gain is directly related to their emotional state. The research was published in the Curr Ther Res Clin Exp on Nov 1975 18(5):675-8.

Nevertheless, peritol or periactin has been shown in numerous studies to stimulate the appetite, increase caloric intake and promote weight gain in normal, healthy adults as well as anorexics. So you may just want to try it if you have trouble gaining weight for whatever reason. You should meet with your doctor to get a prescription for peritol/periactin. You should also watch out for drug interactions with peritol/periactin and you should always follow the recommended dosage as these drugs do make you really drowsy after taking them.

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