By CHAN LEE PENG on February 3rd, 2008

The Most Horrible Diseases Ever to Tremble the World

These horrible diseases really make it difficult for those affected to live normal lives.

Lion Face-Like Syndrome

A man called Yang Hui Ming, suffered from this strange disease since he was four years old. At this young age, a lump as big as a mung bean grew on his left eyelid. Later this lump became bigger and bigger as time passed. When his age reached eight, this lump had already reached a diameter of 3 centimeters. Not long after that, his left forehead protruded to form a knot making his appearance resemble a lion.

Updated: The latest article: The most horrible diseases ever to tremble the world 5 (or The deadliest and most horrible diseases that shock the world).

Premature Senility

At first glance these children seem to be elderly people, perhaps in their 90s. Scientist believes that the occurrence of this disease is due to a minor error in the human genetic code. Most of the children born with these scary diseases only live up to 13 years of age. The premature death is due to the rapidly aging physical process taking place in their bodies. Forty-eight cases of this rare disease have been reported around the world.

Cushing’s Syndrome

Four-year-old Xiao Xin has suffered a strange disease of “Cushing’s syndrome” that causes an increase of 3 to 4kg (or 6.6 to 8.8 pounds) in her weight within half year. Sometimes, within a month, her weight can increase as much as 8kg. Up to now, this four-year-old girl has weighed as much as 70kg (or 154 pounds) while only standing 86 centimeters or approximately 34.4 inches, or less than 3 feet tall. Her weight is reported to be twice that of an obese child.

Blaschko Stripe Disease

This strange and appalling disease covers the body with these rare stripes. This disease was first found by a German Dermatology expert in 1910 while he was dissecting the human body. The stripes establish hidden pattern within human DNA. Many of the congenital and hereditary skin and mucous membranes diseases may show the appearance in accordance with this pattern and finally forms stripes on the human body.

Human Wolf Syndrome

Children who suffer from this disease will grow extremely big, with a dark appearance skin; abundant hairs grow elsewhere from parts of body, particularly near the face until the face is fully covered with variety sizes and textures of wolf-look-like fur. This disease is called human wolf syndrome. The sufferer looks like wolf.

Human Hippo syndrome

A 14-year-old Haitian girl has her face growth with a rare huge tumor weighing 7.7kg, resulting in a severe swelling deformed appearance. The timorous growth caused this child to resemble a hippo.

Elephant Leg Syndrome

This 32-year-old woman has long suffered from a syndrome called “elephant leg”. Her infected left leg is 3 times as large as a normal person’s leg. She often experiences pain in her left leg, and sometimes sticky mucus seeps from her leg. As a result, she often has a high fever as a complication triggered by this terrible syndrome. Over the years, she has to survive with an extremely painful life and doctors are still do not know the cause of this rare disease.

Elephant Arm Syndrome

This syndrome originates with a large black hair mole, which is generally not noticed in its early stages. During this 4-year-old boy early physical developmental stage the black hair mole began growing extensively on his left arm. The normal growth of skin and muscle has been affected.

Ichthyosis

His eyes are being burdened and crushed by both upper and lower stiffed muscles into two black empty holes. Starting from his neck, and further extending to his hands, all parts are completely covered with overlapping layers of fish-like-scales. There are many tracks of blood flowing out from the bulging areas. He has no complete fingers of ten but all his fingers tend to bend, imperfect and cramped as though forming a meat ball. How appalling when looking at them!

Severe Skin Peeling Syndrome

A 13-year-old Vietnamese boy, Nguyen, has suffered from this strange disease over the years. His skin is always in a state of cramping just like he is wearing a tight cloth. Each time when winter time arrives, his skin will peel off massively and thus causing bleeding. Because his facial skin is always experiencing intense tension and tightness, he cannot even close his eyes while sleeping.

Penis Grows on Stomach

A substance resembling a penis grows on top of his stomach creating difficulty in movement. This condition causes much frustration for the patient. This strange disease has made him going crazy for life.

Rough Leg Syndrome

A 23-year-old lady, Wan Cheng, who lives in Jiangsu in Xuzhou, has suffered great pain with this strange disease since she was 7 years old. As time passed her legs have gradually grown in size. Her left leg has grown as much as 2.1-foot in thickness.

Variant Skin Syndrome

A girl has suffered with a rare “variant syndrome” skin disease with great pain. Half of her body appears as charred skin.

Giant Head Syndrome

He was paralyzed at the age of ten since the day he fell off accidentally while playing. Thereafter his head enlargers daily bringing a nightmare to his life. Since contracting this rare disease, his has not grown or lived a normal life, being bedridden and unable to play like a normal child.

Collapsed Face Syndrome

Pachydermoperiostosis

A 19-year-old boy, Ah Meng, has his forehead and scalp muscle cells bulging out as if an alien. One can see an extremely deep track on his head, although there are some visible hairs covered around it. His hands are as big as palms of gorillas, and as rough as the skins of elephants; his fingers are as huge as a broom handle. Doctors diagnosed him to have Pachydermoperiostosis. His forehead is severely deformed by this rarely seen disease.

Premature Aging Syndrome

A 12-year-old girl, Yang Yang, has been suffering from this disease for a long time. This syndrome accelerates her body aging process and leaves her with the appearance of an old woman. Though she is still at the young age of 12, her organs are functioning as slow as someone aged 50 to 60.

Big Stomach Syndrome

This 6-year-old girl from Sichuan Province prefers to hide her head down the stool. She must endure constant pain from the swelling of her stomach. Her stomach has grown as big as a washing basin weighing half of her body weight. At such a young age, she had endured the torture of such horrible disease for nearly four years.

Exophthalmos

This 21-year-old girl suffered from this disease 4 months ago when her eyes suddenly went blind. She has an abnormal bulging of both eyes with patches of redness around them. She said her eyes gave her feeling as though they are going to drop from their sockets. Since she was diagnosed with this disease, her skin surrounding the eyes continually peels. She described this deadly disease as putting her through hell.

Half Face Syndrome

At the age of 22, an age full of colorful life for most people, Min Xiao has to endure ridicule and pain with this disease. She never imagined she could have this bitter a life. 17 years ago, she had a strange disease that caused her to be afflicted with a half face appearance. She is always living in fear and pain as people tease because of her unusual appearance.

Chronic Skin Syndrome

His face, back and feet are terribly covered with lump-like substances. A smelly and sticky liquid flows out from the lumps, making people fear to walk near him. He has been teased and called an alien because of his deformed appearance.

Final remark:

No humiliating and laughing at these unfortunate people, please! Think that, if you’re one of them, will you allow others to humiliate or laugh at you? Please show your caring heart towards these communities. After reading this article, you should appreciate your present appearance. No more grumbling about your look, please! Let’s pray for their well being and healthy!

Comments: 73 | Post a Comment | Trackback URL

b. radley | Feb 3, 2008 | Reply

wow…i had no idea any of these diseases existed.
Chan, your articles are so original. I love your work. Thanks for sharing.
louie jerome | Feb 3, 2008 | Reply

Horrible!! But well written!
valli | Feb 3, 2008 | Reply

I had no idea of these diseases. Really it is unbearable for the sufferer of these…
Judy Sheldon | Feb 3, 2008 | Reply

Chan, looking at these diseased individuals, make me very grateful. Thank you for sharing.
wahyu | Feb 4, 2008 | Reply

i think we should thank to god for our health, theres so many unnormal deases out there. thanks god we are not one of them
Alexa Gates | Feb 4, 2008 | Reply

man…i feel so bad for those people! I never would have guessed that these diseases existed…
Darlene MCFarlane | Feb 4, 2008 | Reply

I have seen a few of the people you have listed here on a TV special. It isn’t until we see something like this that we realize how very lucky we are. The children with Progeria and the girl with Human Hippo syndrome touched me the most. I remember how happy the kids with Progeria were in spite of knowing their fate and how the Haitian girl cried because she wanted so much to be like other kids. How unbearable it must be for the people you listed above and others like them.

Chan, you presented this article very well.
Thank you.
Gbeminiyi Akanmu(Neyo) | Feb 9, 2008 | Reply

Those pictures are bizzare.Those of us that are normal have enough reasons to thank God.
jo | Feb 10, 2008 | Reply

i guess we should consider ourselves blessed because this isn”t an affliction on our children or ourselves but we must always remember they are humans and have feelings and no one should ever make them feel bad. these are not bizzare, they are some kind mix-up, that could happen to any of us. God would most likely want us to count our blesses and never say that we are normal and they are not.
UnKnown | Mar 19, 2008 | Reply

THATS HELLA NASTY!!!!!!!!!!!!!!!!!!!!!!
BAD TO PUT NAME ON INERNET | Mar 31, 2008 | Reply

THESE POOR PEOPLE I FEEL SO SO SO SORRY FOR THEM THEY PROBABLY THINK THEY LIVE IN HELL
UnKnown | Apr 15, 2008 | Reply

Ouch, these are pretty bad! Poor people, have to say though couldnt look for that long.. Felt kinda ill.
Anhtar | Apr 18, 2008 | Reply

Might as well go kill yourself if like that.

Whatkind of life is like that when people are a afraid to go near you, look at you with pity, fear, disgust… sigh. They have no future and who wants to take care of them besides their father and mother?

Would any of you willing to marry and take care of these pitiful individuals? I think very very few would consider that option…
yo yo man | Jun 8, 2008 | Reply

theese poor people if some people like us have horrible lives you have another thing comming
poor people
francesca | Aug 13, 2008 | Reply

i think that it is horribile and that if they came where we are they would be bullied
francesca | Aug 13, 2008 | Reply

i would hate to be like them people staring at you laughing and pointing i mean like they are still human they are just like us exept they have a desise
Insert Name Here | Oct 2, 2008 | Reply

Well written! Gives me a whole new sight of diseases
joana | Oct 25, 2008 | Reply

These made me cry.
name | Oct 28, 2008 | Reply

ok, first of all the “hippo girl” … it was a tumor, and Maury totally fixed that.
name | Oct 28, 2008 | Reply

The last one looks like acute psoriasis. I have a mild form of it.
KING DICK | Nov 16, 2008 | Reply

I think some of these could of been prevented if they were taken care of at an early stage of its developement. Some of these people are dumb not unfortunate. IF YOU SEE A BLACK MOLE, CUT IT OFF.
Youlanada | Dec 3, 2008 | Reply

thats groes!!!!!!!!!!!!!!!!
JustClever | Dec 5, 2008 | Reply

Please guys pray for these people and make a vow not to tease those who are less fortunate.
shah | Jan 6, 2009 | Reply

tuba Allah karam karay
gr8 | Jan 29, 2009 | Reply

could these be the after-effects of the Nuclear bomb and chemicals sprayed on the Asian continent by the U.S.A. ?
Brittnei Belk | Feb 11, 2009 | Reply

Im sure, that if people new that a black mole was bad overthere they would get it cut off. but were talking about people who are less fortunate so you cant just say there stupid. maybe they didnt have the money for it. and theres nothing they can do. and ben dover, you are a sad exuse for life… do you really care none for people except yourself? what kind of selfish fool are you.
beef eater | Mar 9, 2009 | Reply

hahahahahah they suck. those people are so ugly. oh my god soo ugly groooooss
CHAN LEE PENG | Mar 12, 2009 | Reply

To John Harris,

Thanks for your support and for clearing out thing. You’re right! Think of that, if you’re one of them, will you allow others to humilate or laugh at you? Where’s your caring heart? Where’s your benevolence? You should feel sorry to these unfortunate communities.
Joe | Mar 12, 2009 | Reply

These people are picked on because of their looks,no one should be picked on just because of looks caused by diseases. These people are human and are no different to us. People are so cruel to people who have disorders or diseases. These people are propably really nice, while others make their lives hell and really crap. Nobody should pick on someone because of differences.

Hopefully,everybody will learn that someday. And you should too.
Nick | Mar 13, 2009 | Reply

I feel so sorry for those poor people!!!! How can you horrible people laugh at them? huh? if you had any of those diseases you would not think it is funny. To all those people living with those awful diseases, you inspire me to be able to live like that. Never give up!!
jerry manders | Mar 15, 2009 | Reply

“uhh.. me no rikey”
Bone | Mar 16, 2009 | Reply

Oh man, half-face syndrome guy would be a hollywood heart-throb if all we ever saw of him were his angled self-contrived myspace photos.
Charlie D | Mar 16, 2009 | Reply

people not marrying these retards is how natural selection prevents these diseases from ruining the lives of other people
Ballzonia | Mar 17, 2009 | Reply

These people need to get lives and stop moping around and being lazy.

Their disease doesn’t excuse them from acquiring a normal job.

Equality=happiness
Observer | Mar 22, 2009 | Reply

god, help us…
Michael Hunt | Mar 22, 2009 | Reply

Umm interesting article but the grammar was awful!
Missy | Mar 23, 2009 | Reply

These poor people God bless them and I hope they find happiness and peace in their lives.
Mandy | Mar 23, 2009 | Reply

I knew a girl who was born without bones in half her face.

Fortunately, we live in a country with free health care, and she was able to get surgery at birth. Half of her face structure was made out of a titanium mesh. I thought it was pretty cool at the time.
Rebecca | Mar 23, 2009 | Reply

“Premature Aging Syndrome” is called Progeria.
Tommy | Mar 23, 2009 | Reply

If there was a god why would he let this happen to people?
CHAN LEE PENG | Mar 23, 2009 | Reply

To Rebecca,

Thanks for telling me.

To all readers,

Thanks for your support and thanks for pointing out my shortcomings. My wisdom grows with your comments. Thanks again. :-d

Take care, stay well and be happy.

Regards,
Chan
emily | Mar 24, 2009 | Reply

i feel bad for these people!!!!!
Damn | Mar 24, 2009 | Reply

p.s.

I think my gf has giant head syndrome too, she’s a bit of a know all…

p.p.s.

why is my previous comment posted twice? meh, must be my giant mutant fingers!
Zach | Apr 5, 2009 | Reply

Chan Lee Peng you have the worst GRAMMAR ever to tremble the world!
Judy Sheldon | Apr 6, 2009 | Reply

This is to Zach, I wonder how many languages you understand? I think Chan Lee Peng is amazing to be able to present an article half as well in a language that if of another birth place. Chan has other articles here in Spanish too. I consider this writer to be very accomplished. I make mistakes in English, and it my native tongue. Who doesn’t?

Thanks, Chan for sharing your knowledge and hours researching.
David | Apr 6, 2009 | Reply

I prayed for all of these people. =] and anyone else who wants to put a “bad” comment needs to re-think it. =/ seriously grow up and become mature, and be thankful that you have been blessed to live the life that you live now.
Thank You Chan for your article it is good to know someone cares for others.
Cole | Apr 6, 2009 | Reply

I think you should add the “human tree man” who has a severe case of cutaneous horn all over his body. I believe he is an indonesian man.
Just type in “Human Tree Man” into google, you’ll find it.
Its probably the most odd of all of these in my opinion.
It was cured, but still a horrible disease.
CHAN LEE PENG | Apr 6, 2009 | Reply

To Cole,

I’ve included “human tree man” in my article here http://www.healthmad.com/Conditions-and-Diseases/Weirdest-and-Horrible-Diseases-You-Never-Seen-Before.178437/1

Regards,
Chan
lexi | Apr 20, 2009 | Reply

this is y all of us need 2 look at this n thank god that were not in theyre position thank god im not n i praise god everydaii 4 this
Raven | Apr 21, 2009 | Reply

funny as hell, thanks
ali | Apr 22, 2009 | Reply

thank Allah for my helth how is you americans ar dum how is god is he Allahs wife
Shantanu | Apr 23, 2009 | Reply

I went through the pictures…made me wonder abt being one of them…it’s a bit sad to not be able to look in the mirror and have a respectable affirmation of one’s personality… but then again, I cld be wrong, maybe one does not really need a mirror to feel good…after all , one way or other, it’s only some flesh we tote around…

thank u for posting… will visit more often… ciao!
Shantanu | Apr 23, 2009 | Reply

these people, from a perspective we do not have, could be the 20 most beautiful people in the world…or maybe this could have been what we might might have evolved into… u know… we r all the same … i get that feeling here… hope i hv been able to say wht i felt…

thank u people…
CMharrik | Apr 23, 2009 | Reply

Wow, I feel great dispare for these people. I feel great DISGUST for people who think its funny… Well its not. When I was in school we we studing bulemia and anorexia. Some of the class thought it was funny. Even the dieses are more common then thoses they are still dieses and should be treated as such. Here is an English ad on youtube on how bulemic girls see them selves….in order for the ad to make sence you must watch the whole thing. http://www.youtube.com/watch?v=VywJEankDXs

you are welcome -CMharrik

WOW thanks Chan, This a great article, thanks.
ma | Apr 26, 2009 | Reply

i feel so sorry for those people!
ma | Apr 26, 2009 | Reply

that was gross and sad at the same time
zach | May 15, 2009 | Reply

i think i pissed my pants from laughter
i smoke rocks joe rogen
Me | May 16, 2009 | Reply

I feel so bad for these people and wish I could help, but can’t.
Lisa | May 22, 2009 | Reply

nasty. that’s what we have natural selection for.
mika | Jun 8, 2009 | Reply

I see no difference between “Premature Senility” and “Premature Aging Syndrome.” I also see no difference in “Elephant Leg Syndrome” and “Rough Leg Syndrome.” Again, I see no difference, other than the hernia (does not look like a penis) protruding from “Penis Grows on Stomach” and “Big Stomach Syndrome.” Can you please post a reply or another article that outlines the differences between these diseases?
katya | Jun 10, 2009 | Reply

Why don’t you know what you’re talking about before giving these syndromes and diseases names and stories. You obviously have no idea what they are really called or anything about them, at least do some research first. “Big Stomach Syndrome”? haha, seriously. Stop spreading lies.
... | Jun 22, 2009 | Reply

Poor people…*Cries*
Tiago | Jul 12, 2009 | Reply

Thank You for teaching me about these disease, now I appriciate my present figure even more, after reading this article.
mohit | Jul 23, 2009 | Reply

i thank god that iam not suffering from all these diseases.
but jesus cares for them also, he loves these peopel also .
he has made our face on his palm.the bible says a mother can
forgets his child but he (jesus) will never forsake you.
SANTIAGO | Aug 6, 2009 | Reply

THAT IS WHY YOU SHOULD NEVER MAKE FUN OF ANYONE DUE TO WHAT THEY LOOK LIKE. BECAUSE MOST OF THE TIME IS BECAUSE OF A DISEASE OR A SKIN CONDITION THAT THEY WERE BORN WITH. AND WE ALL KNOW THAT GOD HAS HIS WAY OF PUNSHING YOU, YOU MAY ALL OF A SUDDEN HAVE A FAMILY WITH A DISORDER OR A NEW BORN WITH A DISEASE. JUST THINK TWICE OF WHAT YOU SAY AND WHY YOU ARE GOING TO MAKE FUN OF THE PERSON. KARMA PEOPLE KARMA.
Christina | Aug 17, 2009 | Reply

Most of you haven’t heard of these diseases/syndromes because they don’t exist! “Severe Skin Peeling Syndrome” is actually Harlequin Icthyosis, for instance. It just sounds like you made up terms for 99% of the pictures that you randomly found on google. It’s a travesty – you should be ashamed of yourself. If anyone is looking for an actual medical resource in this page, you’ve come to the wrong place
Jackson | Sep 27, 2009 | Reply

i feel really sorry about anyone who wuld have to go through i sit and wonder how do these pople even make through the day
Uma Shankari | Sep 30, 2009 | Reply

I had to quickly scroll over some of the pictures since I couldn’t bear to see them. Names of certain conditions have been invented by you, isn’t it?
Joel Allard | Oct 6, 2009 | Reply

I’d like to give my thanks to the author for bringing a light to these unfortunate people. The names for their conditions my be wrong but the person still exists or did exist. It takes a willpower unknown to most of us just for these ones to survive without the need of a padded cell. Unlike them most of the rest of the world carries their ugliness and disfigurment on the inside. We as a people should care for and protect them in the hopes that they can teach us to be as strong.
Robby | Oct 15, 2009 | Reply

man thats gotta stink… but were no differint
lena | Oct 16, 2009 | Reply

Oh my God. I had no idea these diseases existed in this nasty-horrible world. It was a well-written article that informed me about those diseases, good work, keep up… P.S. I loved your last comment. Thank you
Guruchild | Oct 17, 2009 | Reply

Why should I feel bad for these people just because they have minor physical ailments? My mental pain is far greater than theirs. They need to get over it and be grateful that their mentality is not diseased.
divya iyer | Nov 19, 2009 | Reply

very well written but aren’t these diseases infectious or contagious?so how are people supposed to get near them without even the minutest displeasure?